当前位置:蚂蚁文档网 > 述职报告 > rmhTNF联合顺铂腔内注射治疗恶性浆膜腔积液的临床观察

rmhTNF联合顺铂腔内注射治疗恶性浆膜腔积液的临床观察

时间:2022-04-14 09:43:15 浏览次数:

zoޛ)j馚3EMum579Im^tImm:㍽ONu(NONki]-t׍7ܞH~j^M6^4m5}N4i
Xƥ9~LZТZ)^NgjXI~tۓ۞G]4E~H?@Ge8Ј 0}4}j~2(xR=$MONw|m x~9EoGλmCӝԣu(Nvvisӝmj++Ȭ}-m;:Luo7L}]5k3EhS4V"http://www.jszgctd.com/zl/zongjie/" target="_blank" class="keylink">总结了不少临床经验,如剂量相关性、恶性胸水的疗效优于恶性腹水等[12-13],但对于rmhTNF联合化疗药物治疗恶性浆膜腔积液的报道甚少。

本研究对比分析了rmhTNF联合顺铂及顺铂单药治疗恶性浆膜腔积液,结果显示,rmhTNF联合顺铂疗效更好,能更为有效地提高疾病控制率,同时显著提高患者的生存质量,值得临床推广。

参考文献

[1]王敬,文庆莲.重组人血管内皮抑素治疗恶性胸腹腔积液的研究进展[J].肿瘤预防与治疗,2014,27(3):145-149.

[2]陈建清,康美玲,钟小红,等.TIL与顺铂治疗恶性胸腔积液的疗效比较[J].实用癌症杂志,2011,26(1):53-55.

[3]陈彪,徐细明,余婷婷,等.力尔凡联合铂类药物胸腔内置管灌注化疗治疗恶性胸水的Meta分析[J].武汉大学学报(医学版),2013,34(5):755-761.

[4] Suganuma M,Okabe S,Marino M W,et al.Essential role of tumor necrosis factor α(TNF-α) in tumor promotion as revealed by TNF-α-deficient mice[J].Cancer Res,1999,59(18):4516-4518.

[5] Pikarsky E,Porat R M,Stein I,et al.NF-kappaB functions as a tumour promoter in inflammation-associated cancer[J].Nature,2004,431(7007):461-466.

[6] Balkwill F.Tumour necrosis factor and cancer[J].Nat Rev Cancer,2009,9(5):361-371.

[7] Talmadge J E,Tribble H R,Pennington R W,et al.Immunomodulatory and immunotherapeutic properties of recombinant gamma-interferon and recombinant tumor necrosis factor in mice[J].Cancer Res,1987,47(10):2563-2570.

[8] Lu Y,Yang W,Qin C,et al.Responsiveness of stromal fibroblasts to IFN-gamma blocks tumor growth via angiostasis[J].J Immunol,2009,183(10):6413-6421.

[9] Lejeune F J,Liénard D,Matter M,et al.Efficiency of recombinant human TNF in human cancer therapy[J].Cancer Immun,2006,6:6.

[10] Jung M,Dimtchev A,Velena A,et al.Combining radiation therapy with interstitial radiation-inducible TNF-α expression for locoregional cancer treatment[J].Cancer Gene Ther,2011,18(3):189-195.

[11] Johansson A,Hamzah J,Payne C J,et al.Tumor-targeted TNFα stabilizes tumor vessels and enhances active immunotherapy[J].Proc Natl Acad Sci U S A,2012,109(20):7841-7846.

[12]李焱,魏東,张涛,等.rmhTNF治疗恶性腹腔积液的疗效及其影响因素分析[J].中国肿瘤生物治疗杂志,2009,16(4):410-412.

[13]朱凯,张爱萍,陈胜佳,等.肿瘤坏死因子治疗肺癌恶性胸腔积液的临床观察[J].海峡药学,2014,26(4):105-106.

(收稿日期:2017-07-29)

推荐访问:浆膜 注射 临床 腔内 积液

猜你喜欢